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Hum Mol Genet. 2010 May 1;19(9):1856-62. doi: 10.1093/hmg/ddq057. Epub 2010 Feb 10.

Genetic variants in ABO blood group region, plasma soluble E-selectin levels and risk of type 2 diabetes.

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  • 1Department of Nutrition, Harvard School of Public Health, Boston, MA 02115, USA. nhlqi@channing.harvard.edu

Abstract

Blood soluble E-selectin (sE-selectin) levels have been related to various conditions such as type 2 diabetes. We performed a genome-wide association study among women of European ancestry from the Nurses' Health Study, and identified genome-wide significant associations between a cluster of markers at the ABO locus (9q34) and plasma sE-selectin concentration. The strongest association was with rs651007, which explained approximately 9.71% of the variation in sE-selectin concentrations. SNP rs651007 was also nominally associated with soluble intracellular cell adhesion molecule-1 (sICAM-1) (P = 0.026) and TNF-R2 levels (P = 0.018), independent of sE-selectin. In addition, the genetic-inferred ABO blood group genotypes were associated with sE-selectin concentrations (P = 3.55 x 10(-47)). Moreover, we found that the genetic-inferred blood group B was associated with a decreased risk (OR = 0.44, 0.27-0.70) of type 2 diabetes compared with blood group O, adjusting for sE-selectin, sICAM-1, TNF-R2 and other covariates. Our findings indicate that the genetic variants at ABO locus affect plasma sE-selectin levels and diabetes risk. The genetic associations with diabetes risk were independent of sE-selectin levels.

PMID:
20147318
[PubMed - indexed for MEDLINE]
PMCID:
PMC2850622
Free PMC Article

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