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FEBS Lett. 2010 Apr 2;584(7):1359-66. doi: 10.1016/j.febslet.2010.02.013. Epub 2010 Feb 8.

The Cvt pathway as a model for selective autophagy.

Author information

  • 1Life Sciences Institute, University of Michigan, Ann Arbor, MI 48109-2216, USA.

Abstract

Autophagy is a highly conserved, ubiquitous process that is responsible for the degradation of cytosolic components in response to starvation. Autophagy is generally considered to be non-selective; however, there are selective types of autophagy that use receptor and adaptor proteins to specifically isolate a cargo. One type of selective autophagy in yeast is the cytoplasm to vacuole targeting (Cvt) pathway. The Cvt pathway is responsible for the delivery of the hydrolase aminopeptidase I to the vacuole; as such, it is the only known biosynthetic pathway that utilizes the core machinery of autophagy. Nonetheless, it serves as a model for the study of selective autophagy in other organisms.

Copyright 2010 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.

PMID:
20146925
[PubMed - indexed for MEDLINE]
PMCID:
PMC2843786
Free PMC Article

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