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Curr Biol. 2010 Feb 9;20(3):R101-3. doi: 10.1016/j.cub.2010.01.001.

Cell cycle: the art of multi-tasking.

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  • 1Chromosome Segregation Laboratory, Cancer Research UK London Research Institute, 44 Lincoln's Inn Fields, London WC2A 3PX, UK.


Separase is the protease that cleaves the cohesive link between sister chromatids to trigger chromosome segregation in mitosis and meiosis. This enzyme is known to orchestrate additional mitotic events and we now gain new insight into how it promotes cytokinesis in the nematode Caenorhabditis elegans.

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