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Am J Drug Alcohol Abuse. 2010 Jan;36(1):46-51. doi: 10.3109/00952990903544844.

The relationship between antidepressant use and smoking cessation in pregnant women in treatment for substance abuse.

Author information

  • 1The Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA. mchisol1@jhmi.edu

Abstract

BACKGROUND:

Bupropion's efficacy for smoking cessation in pregnant women is unknown.

OBJECTIVES:

To determine if substance-dependent women prescribed bupropion smoked fewer cigarettes/day than those prescribed citalopram/escitalopram or no antidepressant medication.

METHODS:

Comparison of smoking in bupropion (n = 11), citalopram/escitalopram (n = 17), and no antidepressant (n = 28) groups.

RESULTS AND CONCLUSIONS:

Trend for greater decrease in smoking for the bupropion vs. citalopram/escitalopram group [-6.4 vs. -.4 cigarettes/day (p = .276)], although the bupropion decrease was similar to that seen in the no antidepressant group [-5.3 cigarettes/day].

SCIENTIFIC SIGNIFICANCE:

Data support continued study of bupropion in depressed pregnant substance-dependent smokers.

PMID:
20141396
[PubMed - indexed for MEDLINE]
PMCID:
PMC2925391
Free PMC Article

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