Source
The Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA. mchisol1@jhmi.edu
Abstract
BACKGROUND:
Bupropion's efficacy for smoking cessation in pregnant women is unknown.
OBJECTIVES:
To determine if substance-dependent women prescribed bupropion smoked fewer cigarettes/day than those prescribed citalopram/escitalopram or no antidepressant medication.
METHODS:
Comparison of smoking in bupropion (n = 11), citalopram/escitalopram (n = 17), and no antidepressant (n = 28) groups.
RESULTS AND CONCLUSIONS:
Trend for greater decrease in smoking for the bupropion vs. citalopram/escitalopram group [-6.4 vs. -.4 cigarettes/day (p = .276)], although the bupropion decrease was similar to that seen in the no antidepressant group [-5.3 cigarettes/day].
SCIENTIFIC SIGNIFICANCE:
Data support continued study of bupropion in depressed pregnant substance-dependent smokers.