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    Nat Genet. 2010 Mar;42(3):197-9. Epub 2010 Feb 7.

    Common variants near TERC are associated with mean telomere length.

    Codd V, Mangino M, van der Harst P, Braund PS, Kaiser M, Beveridge AJ, Rafelt S, Moore J, Nelson C, Soranzo N, Zhai G, Valdes AM, Blackburn H, Mateo Leach I, de Boer RA, Kimura M, Aviv A; Wellcome Trust Case Control Consortium, Goodall AH, Ouwehand W, van Veldhuisen DJ, van Gilst WH, Navis G, Burton PR, Tobin MD, Hall AS, Thompson JR, Spector T, Samani NJ.

    Source

    Department of Cardiovascular Sciences, University of Leicester, Glenfield Hospital, Leicester, UK.

    Erratum in

    • Nat Genet. 2010 Mar;42(3):following 199. Aviv, Abraham [added]; Kimura, Masayuki [added].

    Abstract

    We conducted genome-wide association analyses of mean leukocyte telomere length in 2,917 individuals, with follow-up replication in 9,492 individuals. We identified an association with telomere length on 3q26 (rs12696304, combined P = 3.72 x 10(-14)) at a locus that includes TERC, which encodes the telomerase RNA component. Each copy of the minor allele of rs12696304 was associated with an approximately 75-base-pair reduction in mean telomere length, equivalent to approximately 3.6 years of age-related telomere-length attrition.

    PMID:
    20139977
    [PubMed - indexed for MEDLINE]

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