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Nat Neurosci. 2010 Mar;13(3):284-6. doi: 10.1038/nn.2497. Epub 2010 Feb 7.

Opioids activate brain analgesic circuits through cytochrome P450/epoxygenase signaling.

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  • 1Center for Neuropharmacology and Neuroscience, Albany Medical College, Albany, New York, USA.

Abstract

To assess the importance of brain cytochrome P450 (P450) activity in mu opioid analgesic action, we generated a mutant mouse with brain neuron-specific reductions in P450 activity; these mice showed highly attenuated morphine antinociception compared with controls. Pharmacological inhibition of brain P450 arachidonate epoxygenases also blocked morphine antinociception in mice and rats. Our findings indicate that a neuronal P450 epoxygenase mediates the pain-relieving properties of morphine.

PMID:
20139973
[PubMed - indexed for MEDLINE]
PMCID:
PMC2828325
Free PMC Article
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