Biosci Biotechnol Biochem. 2010;74(2):443-6. Epub 2010 Feb 7.

The pathway of leucine to mevalonate in halophilic archaea: efficient incorporation of leucine into isoprenoidal lipid with the involvement of isovaleryl-CoA dehydrogenase in Halobacterium salinarum.

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Department of Earth and Planetary Sciences, Graduate School of Sciences, Kyushu University, Fukuoka, Japan. nyama@geo.kyushu-u.ac.jp

Abstract

The pathway of leucine to mevalonate, which has attracted attention in the study of the biosynthesis of isoprenoid in parasitic protozoa and myxobacterium, was observed in the biosynthesis of the lipid core in halophilic archaea. The involvement of isovaleryl-CoA dehydrogenase was strongly suggested, with stereospecific conversion of the diastereotopic methyl group of leucine to isoprenoidal lipid.

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