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FEBS Lett. 2010 Apr 2;584(7):1280-6. doi: 10.1016/j.febslet.2010.02.001. Epub 2010 Feb 5.

Current knowledge of the pre-autophagosomal structure (PAS).

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  • 1Advanced Research Organization, Integrated Research Institute, Tokyo Institute of Technology, Midori-ku, Yokohama, Japan.


Autophagy is a system for degradation of bulk cellular components in lytic compartments, vacuoles, or lysosomes when eukaryotic cells face with nutrient starvation. In this review, we focus on the pre-autophagosomal structure (PAS), a functional entity responsible for autophagosome formation in Saccharomyces cerevisiae, and discuss its relevance to autophagy in mammalian cells.

Copyright 2010 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.

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