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Bull Math Biol. 2010 Aug;72(6):1383-407. doi: 10.1007/s11538-009-9497-4. Epub 2010 Feb 5.

Mathematical modelling of the Aux/IAA negative feedback loop.

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  • 1School of Mathematical Sciences, University of Nottingham, University Park, Nottingham, NG7 2RD, UK. alistair.middleton@nottingham.ac.uk

Abstract

The hormone auxin is implicated in regulating a diverse range of developmental processes in plants. Auxin acts in part by inducing the Aux/IAA genes. The associated pathway comprises multiple negative feedback loops (whereby Aux/IAA proteins can repress Aux/IAA genes) that are disrupted by auxin mediating the turnover of Aux/IAA protein. In this paper, we develop a mathematical model of a single Aux/IAA negative feedback loop in a population of identical cells. The model has a single steady-state. We explore parameter space to uncover a number of dynamical regimes. In particular, we identify the ratio between the Aux/IAA protein and mRNA turnover rates as a key parameter in the model. When this ratio is sufficiently small, the system can evolve to a stable limit cycle, corresponding to an oscillation in Aux/IAA expression levels. Otherwise, the steady-state is either a stable-node or a stable-spiral. These observations may shed light on recent experimental results.

PMID:
20135237
[PubMed - indexed for MEDLINE]
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