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Pediatr Radiol. 2010 May;40(5):657-68; quiz 792-3. doi: 10.1007/s00247-009-1503-3. Epub 2010 Feb 5.

Chronic granulomatous disease.

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  • 1Department of Radiology, Cincinnati Children's Hospital Medical Center, 3333 Burnet Ave., ML# 5031, Cincinnati, OH 45229, USA. Alexander.Towbin@cchmc.org


Chronic granulomatous disease (CGD) is a rare congenital immunodeficiency characterized by recurrent bacterial and fungal infections as well as granuloma formation. The manifestations of this disease can involve single or multiple organ systems. The lungs are the most commonly affected organ; however, lymphatic, hepatic, skeletal, gastrointestinal, genitourinary, head and neck, and central nervous system involvement have also been described. Most patients present with symptoms in their first few years of life. Due to the nonspecific manner in which patients present, the pediatric radiologist may be among the first to recognize the pattern of infection, inflammation, and granuloma formation leading to a diagnosis of CGD. The purpose of this paper is to review the imaging findings of CGD that can manifest throughout the body.

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