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Science. 2010 Feb 19;327(5968):996-1000. doi: 10.1126/science.1184208. Epub 2010 Feb 4.

Regulation of alternative splicing by histone modifications.

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  • 1National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA.

Abstract

Alternative splicing of pre-mRNA is a prominent mechanism to generate protein diversity, yet its regulation is poorly understood. We demonstrated a direct role for histone modifications in alternative splicing. We found distinctive histone modification signatures that correlate with the splicing outcome in a set of human genes, and modulation of histone modifications causes splice site switching. Histone marks affect splicing outcome by influencing the recruitment of splicing regulators via a chromatin-binding protein. These results outline an adaptor system for the reading of histone marks by the pre-mRNA splicing machinery.

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PMID:
20133523
[PubMed - indexed for MEDLINE]
PMCID:
PMC2913848
Free PMC Article

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