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FEBS Lett. 1991 Mar 25;280(2):363-6.

Characterization of human deoxycytidine kinase. Correlation with cDNA sequences.

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  • 1Medical Nobel Institute, Department of Biochemistry, Karolinska Institutet, Stockholm, Sweden.


Existing data on the structure of human deoxycytidine kinase (dCK) diverge. A monomeric 60 kDa form has been isolated and the cloning of a cDNA coding for 626 amino acids corresponding to a 71 kDa protein has been reported. However, pure dCK isolated from leukemic spleen is a dimer of 30 kDa subunits. Amino acid sequences of peptides from digests of this protein are now presented. None of the peptide structures obtained correspond to the cDNA for the 71 kDa protein, but to a cDNA for a 30.5 kDa dCK recently cloned. Furthermore, homology of the peptide sequences od dCK to parts of thymidine kinases and protein-tyrosine kinases are detected.

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