Display Settings:

Format

Send to:

Choose Destination
See comment in PubMed Commons below
Am J Addict. 2010 Jan-Feb;19(1):47-52. doi: 10.1111/j.1521-0391.2009.00009.x.

Effect of cocaine use on methadone pharmacokinetics in humans.

Author information

  • 1Department of Psychiatry, University of California San Francisco, San Francisco, California, USA. elinore.mccance-katz@ucsf.edu

Abstract

Chronic cocaine use has been shown to significantly decrease buprenorphine concentrations in the blood with potential for adverse events and poor treatment response. In this study, we investigated whether a similar drug interaction occurred between cocaine and methadone. In a retrospective analysis, methadone pharmacokinetics were compared for those who were either regular cocaine users (N = 16) or with intermittent or no cocaine use (N = 23). Participants who used cocaine regularly showed a significant decrease in C(min) (p = .04) and a trend for decreased AUC (p = .09) and more rapid methadone clearance (p = .08). Regular cocaine use may adversely impact treatment outcomes for opioid dependence in those receiving methadone maintenance by decreasing methadone exposure.

PMID:
20132121
[PubMed - indexed for MEDLINE]
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Loading ...
    Write to the Help Desk