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Am J Addict. 2010 Jan-Feb;19(1):47-52. doi: 10.1111/j.1521-0391.2009.00009.x.

Effect of cocaine use on methadone pharmacokinetics in humans.

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  • 1Department of Psychiatry, University of California San Francisco, San Francisco, California, USA. elinore.mccance-katz@ucsf.edu


Chronic cocaine use has been shown to significantly decrease buprenorphine concentrations in the blood with potential for adverse events and poor treatment response. In this study, we investigated whether a similar drug interaction occurred between cocaine and methadone. In a retrospective analysis, methadone pharmacokinetics were compared for those who were either regular cocaine users (N = 16) or with intermittent or no cocaine use (N = 23). Participants who used cocaine regularly showed a significant decrease in C(min) (p = .04) and a trend for decreased AUC (p = .09) and more rapid methadone clearance (p = .08). Regular cocaine use may adversely impact treatment outcomes for opioid dependence in those receiving methadone maintenance by decreasing methadone exposure.

[PubMed - indexed for MEDLINE]
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