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J Headache Pain. 2010 Apr;11(2):171-3. doi: 10.1007/s10194-010-0188-1. Epub 2010 Feb 4.

Sporadic hemiplegic migraine and CREST syndrome.

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  • 1Neurology, Hospital de Clínicas, Av. Córdoba 2351, Buenos Aires, Argentina.


Hemiplegic migraines are characterised by attacks of migraine with aura accompanied by transient motor weakness. There are both familial and sporadic subtypes, which are now recognised as separate entities by the International Classification of Headache Disorders, edition II (ICHD-II). The sporadic subtype has been associated with other medical conditions, particularly rheumatological diseases. We report the case of a woman with sporadic hemiplegic migraine associated with CREST syndrome (calcinosis, Raynaud's phenomenon, esophageal dysmotility, sclerodactyly and telangiectasia). Since there is a close relationship between migraine and Raynaud's phenomenon, it could be speculated that the sporadic hemiplegic migraines in our patient might be secondary to CREST syndrome.

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