Nuclear poly(a)-binding proteins and nuclear degradation: take the mRNA and run?

Mol Cell. 2010 Jan 15;37(1):3-5. doi: 10.1016/j.molcel.2009.12.029.

Abstract

Recent work from Lemay et al. (2010) in this issue of Molecular Cell reveals a role for a nuclear poly(A)-binding protein in promoting degradation of small nucleolar RNAs (snoRNAs) by the nuclear exosome.

Publication types

  • Comment

MeSH terms

  • Cell Nucleus / metabolism*
  • Exosomes / physiology
  • Gene Deletion
  • Models, Genetic
  • Poly(A)-Binding Proteins / genetics
  • Poly(A)-Binding Proteins / physiology*
  • RNA, Messenger / metabolism*
  • RNA, Small Nucleolar / metabolism
  • Schizosaccharomyces / genetics*
  • Schizosaccharomyces pombe Proteins / genetics
  • Schizosaccharomyces pombe Proteins / physiology*

Substances

  • Poly(A)-Binding Proteins
  • RNA, Messenger
  • RNA, Small Nucleolar
  • Schizosaccharomyces pombe Proteins