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J Clin Ultrasound. 2010 Mar-Apr;38(3):113-7. doi: 10.1002/jcu.20673.

Further observations on the empty "amnion sign".

Author information

  • 1Department of Radiology, University of California, San Francisco, L374, 505 Parnassus Avenue, San Francisco, CA 94143-0628, USA.

Abstract

OBJECTIVE:

To assess the positive predictive value of the empty "amnion sign" (visualization of an amnion without concomitant visualization of an embryo) for the diagnosis of early pregnancy failure.

METHODS:

Retrospective study of 882 1st trimester sonographic examinations with abnormal findings among women who were threatening to abort. Eight hundred six met the inclusion criteria.

RESULTS:

In the study cohort 286 (35.5%) had no identifiable embryo and 71 of those without an identifiable embryo had a visible amnion (24.8%). The breakdown of the mean sac diameter of the study cohort was as follows: those measuring less than 16 mm (n = 16); those measuring 16-20 mm (n = 20); those measuring 21 mm or more (n = 35). Sixty-eight of the 71 patients had adequate follow-up. Pregnancy failure was confirmed in all 68 patients (positive predictive value = 100%).

CONCLUSIONS:

The data from this study indicate that visualization of an amnion without concomitant visualization of an embryo (the empty "amnion sign") confirms pregnancy failure regardless of the mean sac diameter and with a sufficiently high positive predictive value to make a definitive diagnosis.

Copyright 2010 Wiley Periodicals, Inc.

PMID:
20127965
[PubMed - indexed for MEDLINE]
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