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Am J Med Genet B Neuropsychiatr Genet. 2010 Jun 5;153B(4):973-9. doi: 10.1002/ajmg.b.31061.

SNPs in CAST are associated with Parkinson disease: a confirmation study.

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  • 1Department of Biostatistics and Bioinformatics, Duke University, Durham, North Carolina, USA.


Using data from the National Institutes of Neurological disease and Stroke's (NINDS) study of Parkinson disease (PD), we recently reported that single nucleotide polymorphisms (SNPs) in a region containing the Calpastatin (CAST) gene were associated with PD. Here we follow up this finding with an analysis of the Center for Inherited Disease Research's (CIDR) genome-wide association study in familial PD. After adjusting for population stratification and multiple testing, we find a significant association (P = 0.0167) between PD and SNP rs1559085 in CAST. These findings confirm CAST/PD associations in a second, independent, dataset and suggest that CAST be prioritized for further investigation.

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