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Am J Med Genet B Neuropsychiatr Genet. 2010 Jun 5;153B(4):973-9. doi: 10.1002/ajmg.b.31061.

SNPs in CAST are associated with Parkinson disease: a confirmation study.

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  • 1Department of Biostatistics and Bioinformatics, Duke University, Durham, North Carolina, USA. andrew.s.allen@duke.edu

Abstract

Using data from the National Institutes of Neurological disease and Stroke's (NINDS) study of Parkinson disease (PD), we recently reported that single nucleotide polymorphisms (SNPs) in a region containing the Calpastatin (CAST) gene were associated with PD. Here we follow up this finding with an analysis of the Center for Inherited Disease Research's (CIDR) genome-wide association study in familial PD. After adjusting for population stratification and multiple testing, we find a significant association (P = 0.0167) between PD and SNP rs1559085 in CAST. These findings confirm CAST/PD associations in a second, independent, dataset and suggest that CAST be prioritized for further investigation.

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