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Pflugers Arch. 2010 Jul;460(2):437-50. doi: 10.1007/s00424-010-0788-2. Epub 2010 Feb 4.

Transient receptor potential channelopathies.

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  • 1Laboratory Ion Channel Research, Department of Molecular Cell Biology, KU Leuven, Campus Gasthuisberg, Herestraat 49, bus 802, Leuven, Belgium. Bernd.Nilius@med.kuleuven.be


In the past years, several hereditary diseases caused by defects in transient receptor potential channels (TRP) genes have been described. This review summarizes our current knowledge about TRP channelopathies and their possible pathomechanisms. Based on available genetic indications, we will also describe several putative pathological conditions in which (mal)function of TRP channels could be anticipated.

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