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Arq Bras Endocrinol Metabol. 2009 Nov;53(8):1005-11.

Relationship between insulin and hypogonadism in men with metabolic syndrome.

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  • 1Departamento de Endocrinologia, Hospital das Forças Armadas, Brasília, DF, Brasil.

Abstract

OBJECTIVE:

To evaluate the incidence of hypogonadism in men with metabolic syndrome and its correlation with serum insulin levels.

METHODS:

Observational, transversal study with 80 men with metabolic syndrome. The individuals were divided into two groups: Group 1: 56 patients (70%) with total testosterone > 300 ng/dL (normal gonadal function); Group 2: 24 patients (30%) with total testosterone < 300 ng/dL (hypogonadic).

RESULTS:

The subjects from Group 2 compared to Group 1 presented higher body mass index (BMI), waist and hip circumferences, insulin, homeostasis model assessment insulin resistance index (Homa-IR) and beta cell (Homa-beta), and triglycerides, but lower SHBG and free testosterone values. Inverse correlations between insulin levels and total testosterone and SHBG, as well as between Homa-IR and total testosterone were observed.

CONCLUSION:

In this series of men with metabolic syndrome, hypogonadism was associated with insulin resistance and may be a marker of metabolic abnormalities.

PMID:
20126854
[PubMed - indexed for MEDLINE]
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