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Opt Lett. 2010 Feb 1;35(3):369-71. doi: 10.1364/OL.35.000369.

Comparison of fluorescence tomographic imaging in mice with early-arriving and quasi-continuous-wave photons.

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  • 1Department of Electrical and Computer Engineering, Northeastern University, Boston, Massachusetts 02115, USA.


The highly diffuse nature of light propagation in biological tissue is a major challenge for obtaining high-fidelity fluorescence tomographic images. In this work we investigated the use of time-gated detection of early-arriving photons for reducing the effects of light scatter in mice relative to quasi-cw photons. When analyzing sinographic representations of the measured data, it was determined that early photons allowed a reduction in the measured FWHM of fluorescent targets by a factor of approximately 2-3, yielding a significant improvement in the tomographic image reconstruction quality.

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