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J Atheroscler Thromb. 2010 Feb 26;17(2):165-72. Epub 2010 Feb 3.

Brachial-ankle pulse wave velocity predicts silent cerebrovascular diseases in patients with end-stage renal diseases.

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  • 1Department of Internal Medicine, School of Medicine, Keio University, Tokyo, Japan. washida@sc.itc.keio.ac.jp

Abstract

AIM:

Cerebrovascular disease (CVD) is a major determinant of the prognosis in end-stage renal diseases (ESRD). The purpose of this study was to examine whether factors associated with arterial stiffness contributed to the development of CVD in patients with ESRD.

METHODS:

CVD (lacunes and carotid/intracranial artery stenosis) was evaluated with brain magnetic resonance imaging (MRI), and carotid/intracranial artery magnetic resonance angiography (MRA) in 44 pre-dialytic patients. The severity of CVD was evaluated by the number of lacunes and the degree of stenosis, respectively. The association between CVD and atherosclerotic parameters was evaluated.

RESULTS:

Patients with severe lacunes (n=18) manifested older age, lower diastolic blood pressure, serum creatinine and albumin, and higher CRP and serum calcium than those with absent-moderate lacunes (n=26). When assessed by multivariate analysis, only baPWV was adopted as an independent risk factor for severe lacunes. Furthermore, baPWV and i-PTH were associated with the severity of carotid/intracranial artery stenosis, both of which were independent of other risk factors, including age and diabetes.

CONCLUSIONS:

Arterial stiffness may constitute a novel determinant predicting the severity of CVD in pre-dialytic patients besides classical risk factors.

PMID:
20124736
[PubMed - indexed for MEDLINE]
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