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    Clin Liver Dis. 2010 Feb;14(1):37-48; vii-viii.

    Molecular epidemiology of health care-associated transmission of hepatitis B and C viruses.

    Source

    Division of Viral Hepatitis, National Center for HIV, Hepatitis, TB, and STD Prevention, Centers for Disease Control and Prevention, CDC Mailstop G-37; 1600 Clifton Road, Atlanta, GA 30333, USA. sdh1@cdc.gov

    Abstract

    The term "molecular epidemiology" has been ascribed to a host of different activities that involve gene-sequence analysis. Some examples of molecular epidemiology include modeling exercises of phylogenetic trees to reconstruct epidemics; studies of the evolution of hepatitis C virus (HCV); rates of nucleotide substitution in the hepatitis B virus (HBV) surface (S) gene; variations in the core promoter/pre-core/core region of HBV genotype C from different sources; analysis of HBV surface antigen mutations; molecular clock analyses of the short-term evolution of HCV; and analyses of clades and surface antigen polymorphisms of HBV. However, for most epidemiologists molecular epidemiology of viral hepatitis usually refers to studies of gene-sequence homology in HBV or HCV recovered from people in the community or an institution that allows better characterization and assignment of related clusters of infection.

    PMID:
    20123438
    [PubMed - indexed for MEDLINE]

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