DNA Repair (Amst). 2010 Mar 2;9(3):250-6. Epub 2010 Feb 1.

FANCJ: solving problems in DNA replication.

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Biomedical Research Institute, Ninewells Hospital & Medical School, University of Dundee, DD1 9SY, Scotland, UK. k.hiom@dundee.ac.uk

Abstract

The FANCJ protein (also known as BACH1 and BRIP1) is a DNA helicase that is required to preserve the genetic and structural integrity of the genome in complex eukaryotes. In humans, mutations in FANCJ are associated with the chromosome instability disorder Fanconi's anemia and also with the inherited predisposition early-onset breast cancer. Here I will discuss the contribution of FANCJ to human disease, its role in maintenance of genome stability and some current thoughts on the mechanisms through which this is achieved.

PMID:: 20122882; [PubMed - indexed for MEDLINE]

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FANCJ (BACH1) helicase forms DNA damage inducible foci with replication protein A and interacts physically and functionally with the single-stranded DNA-binding protein. [Blood. 2007]
FANCJ (BACH1) helicase forms DNA damage inducible foci with replication protein A and interacts physically and functionally with the single-stranded DNA-binding protein.
Gupta R, Sharma S, Sommers JA, Kenny MK, Cantor SB, Brosh RM Jr. Blood. 2007 Oct 1; 110(7):2390-8. Epub 2007 Jun 27.
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Review The Fanconi anemia pathway of genomic maintenance.
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Cited by 5 PubMed Central articles

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