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Eur J Med Chem. 2010 May;45(5):1873-9. doi: 10.1016/j.ejmech.2010.01.026. Epub 2010 Jan 20.

The influence of the aziridinyl substituent of benzimidazoles and benzimidazolequinones on toxicity towards normal and Fanconi anaemia cells.

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  • 1School of Chemistry, National University of Ireland, Galway, Ireland.

Abstract

Aziridinyl substituted benzimidazolequinones are more toxic than methoxy analogues towards normal human fibroblast cells (GM00637). The aziridinyl substituent is required for hypersensitive killing of Fanconi anaemia (FA) cells (PD20i) deficient in FANCD2. Despite lacking quinone functionality, 4,7-dimethoxy-N-[(aziridin-2-yl)methyl]benzimidazole also induces hypersensitivity from FA cells, similar to their response towards mitomycin C. Expression of FANCD2 (in PD20:RV) corrects FA cell hypersensitivity supporting cellular response via the FANC pathway.

Copyright (c) 2010 Elsevier Masson SAS. All rights reserved.

PMID:
20122765
[PubMed - indexed for MEDLINE]

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