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Mol Cell. 2010 Jan 29;37(2):153-5. doi: 10.1016/j.molcel.2010.01.010.

WT1 the oncogene: a tale of death and HtrA.

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  • 1MRC Human Genetics Unit and the Institute for Genetics and Molecular Medicine, Edinburgh EH4 2XU, UK.


Here, Hartkamp et al. (2010) identify WT1 as a novel bona fide substrate of the HtrA2/Omi mitochondrial protease and show that this reaction modulates WT1 antiapoptotic activity under cytotoxic stress. This supports an oncogenic function for WT1, with implications for novel chemotherapeutic avenues.

Copyright 2010 Elsevier Inc. All rights reserved.

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