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Nat Cell Biol. 2010 Feb;12(2):106-8. doi: 10.1038/ncb0210-106.

Cohesin and Cdk1: an anaphase barricade.

Author information

  • School of Biomedical Sciences, Faculty of Health, University of Newcastle, NSW 2308, Australia. keith.jones@newcastle.edu.au

Abstract

Separation of sister chromatids at anaphase in metazoan cells requires only the cleavage of the kleisin subunit of centromeric cohesin, but efficient poleward movement of separated sisters requires the associated loss in Cdk1 activity. Activation of the anaphase-promoting complex/cyclosome ensures these events are coordinated.

PMID:
20118997
[PubMed - indexed for MEDLINE]
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