Nat Cell Biol. 2010 Feb;12(2):104-6.

Mitochondria get a Parkin' ticket.

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Goethe University Medical School, Institute of Biochemistry II and Frankfurt Institute for Molecular Life Sciences, Theodor-Stern-Kai 7, Frankfurt a.M., D-60590, Germany.

Abstract

Recent studies have revealed a prominent role of mitochondrial dysfunction in the development of one of the most common neurodegenerative disorders, Parkinson's disease. The ubiquitin ligase Parkin and the protein kinase PINK1, whose mutations are associated with Parkinson's disease, function in a pathway that links ubiquitylation with selective autophagy of damaged mitochondria.

PMID:: 20118996; [PubMed - indexed for MEDLINE]

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