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Psychosomatics. 2010 Jan-Feb;51(1):68-73. doi: 10.1176/appi.psy.51.1.68.

The effect of psychological distress on medication adherence in persons with HIV infection in Nigeria.

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  • 1Dept. of Psychiatry, Lagos State University College of Medicine, Ikeja 100010, Lagos, Nigeria.



A high level of adherence to prescribed antiretroviral (ARV) regimens is required to achieve and maintain suppression of human immunodeficiency virus (HIV) replication and prevent drug resistance.


This study aimed to determine the possible relationship between psychopathology and ARV medication adherence in Nigeria.


Persons with HIV infection (N=182) completed various questionnaires on sociodemographic and clinical details, general psychopathology, self-esteem, and medication adherence.


Low medication adherence was reported in 26.9% of the participants; significant correlates included presence of psychopathology and perceived poor social support.


The success of any intervention policy for HIV-infected persons in sub-Saharan Africa must consider both low level of medication adherence and its associated factors.

[PubMed - indexed for MEDLINE]
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