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J Bacteriol. 2010 Apr;192(7):2009-12. doi: 10.1128/JB.01685-09. Epub 2010 Jan 29.

The physiological stimulus for the BarA sensor kinase.

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  • 1Departamento de Genética Molecular, Instituto de Fisiología Celular, Universidad Nacional Autónoma de México, Mexico City, Mexico.


The two-component signal transduction system (TCS) BarA/UvrY activates transcription of CsrB and CsrC noncoding RNAs, which act by sequestering the RNA-binding global regulatory protein CsrA. Here, we show that the metabolic end products formate and acetate provide a physiological stimulus for this TCS and thus link posttranscriptional regulation by the Csr system to the metabolic state of the cell.

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