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    Science. 1991 Mar 29;251(5001):1597-600.

    Characterization of a human TAR RNA-binding protein that activates the HIV-1 LTR.

    Gatignol A, Buckler-White A, Berkhout B, Jeang KT.

    Laboratory of Molecular Microbiology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892.

    Human immunodeficiency virus type 1 (HIV-1) gene expression is activated by Tat, a virally encoded protein. Tat trans-activation requires viral (trans-activation--responsive; TAR) RNA sequences located in the R region of the long terminal repeat (LTR). Existing evidence suggests that Tat probably cooperates with cellular factors that bind to TAR RNA in the overall trans-activation process. A HeLa complementary DNA was isolated and characterized that encodes a TAR RNA-binding protein (TRBP). TRBP activated the HIV-1 LTR and was synergistic with Tat function.

    PMID: 2011739 [PubMed - indexed for MEDLINE]

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