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FEBS Lett. 2010 Mar 5;584(5):845-51. doi: 10.1016/j.febslet.2009.12.061. Epub 2010 Jan 29.

Dynamin-1 co-associates with native mouse brain BKCa channels: proteomics analysis of synaptic protein complexes.

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  • 1Waggoner Center for Alcohol and Addiction Research, College of Natural Sciences, The University of Texas at Austin, Austin, TX 78712, USA.


In every synapse, a large number of proteins interact with other proteins in order to carry out signaling and transmission in the central nervous system. In this study, we used interaction proteomics to identify novel synaptic protein interactions in mouse cortical membranes under native conditions. Using immunoprecipitation, immunoblotting, and mass spectrometry, we identified a number of novel synaptic protein interactions involving soluble N-ethylmaleimide-sensitive factor attachment protein receptors (SNAREs), calcium-activated potassium channel (BKCa) alpha subunits, and dynamin-1. These novel interactions offer valuable insight into the protein-protein interaction network in intact synapses that could advance understanding of vesicle trafficking, release, and recycling.

Copyright (c) 2010 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.

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