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ACS Nano. 2010 Feb 23;4(2):1049-59. doi: 10.1021/nn901213a.

Host-guest interaction mediated polymeric assemblies: multifunctional nanoparticles for drug and gene delivery.

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  • 1Department of Biologic and Materials Sciences, University of Michigan, Ann Arbor, MI 48109, USA.


Novel core-shell structured nanoassemblies are assembled by a beta-cyclodextrin containing a positively charged host polymer and a hydrophobic guest polymer. The hydrophobic core of these types of assemblies serves as a nanocontainer to load and release the hydrophobic drugs, while the positively charged hydrophilic shell is able to condense the plasmid DNA and achieve its transfection/expression in osteoblast cells. These assemblies may be used as a new generation of multifunctional nanocarriers for simultaneous drug delivery and gene therapy.

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