Improved synthesis of the two-photon caging group 3-nitro-2-ethyldibenzofuran and its application to a caged thymidine phosphoramidite

Org Lett. 2010 Mar 5;12(5):916-9. doi: 10.1021/ol902807q.

Abstract

A new and efficient route to the recently reported 3-nitro-2-ethyldibenzofuran caging group was developed. Furthermore, its installation on a thymidine phosphoramidite is described. This caging group is efficiently removed through light-irradiation at 365 nm.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, Non-P.H.S.

MeSH terms

  • Benzofurans / chemical synthesis*
  • Benzofurans / chemistry*
  • DNA / chemical synthesis
  • DNA / chemistry
  • Organophosphorus Compounds / chemistry*
  • Photons*
  • Thymidine Monophosphate / analogs & derivatives*
  • Thymidine Monophosphate / chemistry*

Substances

  • Benzofurans
  • Organophosphorus Compounds
  • phosphoramidite
  • Thymidine Monophosphate
  • DNA
  • benzofuran