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J Cell Physiol. 2010 May;223(2):289-98. doi: 10.1002/jcp.22066.

MicroRNAs as gatekeepers of apoptosis.

Author information

  • 1Department of Laboratory Medicine & Pathology, University of Minnesota Medical School, Minneapolis, Minnesota 55455, USA. subree@umn.edu

Abstract

Apoptosis is a well-orchestrated cellular mechanism that balances the effects of cell proliferation and cell death. MicroRNAs (miRNAs) have been shown to control cell growth, differentiation, and apoptosis; and can be significantly deregulated in many cancers types. In fact, the ability to evade apoptosis is a hallmark of tumorigenesis. Although the role of miRNAs in the regulation of apoptosis is not fully understood, the recent influx of data strongly suggests that miRNAs play a significant role in regulating programmed cell death, or apoptosis. The genes involved in apoptotic pathways can be broadly classified as pro-apoptotic and anti-apoptotic. Many of these apoptotic genes, irrespective of their positive or negative functional role in apoptosis, are regulated by miRNAs. In this review, we discuss the emerging role of miRNA-mediated gene networks in the control of apoptosis.

PMID:
20112282
[PubMed - indexed for MEDLINE]
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