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J Clin Immunol. 2010 Mar;30(2):221-5. doi: 10.1007/s10875-009-9365-x. Epub 2010 Jan 28.

Plasma IL-17A is increased in new-onset SLE patients and associated with disease activity.

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  • 1Department of Rheumatology, Zhongnan Hospital, Medical College of Wuhan University, Wuhan, China. chenxjane@yahoo.com.cn

Abstract

OBJECTIVE:

To investigate the role of interleukin-17A (IL-17A) and Th17 cell in the pathogenesis of systemic lupus erythematosus (SLE), we studied the plasma IL-17A and the expression of Th17 cell transcription factor RORgammat in Chinese new-onset SLE patients.

METHODS:

Sixty SLE patients aged between 18 and 40 years and 56 age-matched healthy volunteers were involved in the study. Enzyme-linked immunosorbent assay was used to measure plasma IL-17A level, and rea1-time fluorescent quantitative polymerase chain reaction was used to measure RORgammat mRNA.

RESULTS:

The results showed that both IL-17A level and RORgammat mRNA in SLE patients were higher than that of controls. Correlation analysis indicated that plasma IL-17A level was positively correlated with Systemic Lupus Erythematosus Disease Activity Index, not with RORgammat mRNA.

CONCLUSION:

We concluded that IL-17A might play a role in the pathogenesis of SLE and associated with disease activity. RORgammat-determined Th17 cell might be involved with increased IL-17A in SLE but not exclusively the unique source.

PMID:
20107878
[PubMed - indexed for MEDLINE]
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