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N Engl J Med. 2010 Jan 28;362(4):314-9. doi: 10.1056/NEJMoa0904485.

Vaccine-acquired rotavirus in infants with severe combined immunodeficiency.

Author information

  • 1Department of Pediatrics, Section of Allergy and Immunology, Baylor College of Medicine, Texas Children's Hospital, Houston, TX 77030, USA.

Abstract

Live pentavalent human-bovine reassortant rotavirus vaccine is recommended in the United States for routine immunization of infants. We describe three infants, two with failure to thrive, who had dehydration and diarrhea within 1 month after their first or second rotavirus immunization and subsequently received a diagnosis of severe combined immunodeficiency. Rotavirus was detected, by means of reverse-transcriptase-polymerase-chain-reaction (RT-PCR) assay, in stool specimens obtained from all three infants, and gene-sequence analysis revealed the presence of vaccine rotavirus. These infections raise concerns regarding the safety of rotavirus vaccine in severely immunocompromised patients.

2010 Massachusetts Medical Society

PMID:
20107217
[PubMed - indexed for MEDLINE]
PMCID:
PMC4103739
Free PMC Article
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