Format

Send to:

Choose Destination
See comment in PubMed Commons below
Physiol Behav. 2010 Jun 1;100(3):245-9. doi: 10.1016/j.physbeh.2010.01.011. Epub 2010 Jan 25.

Mini-review: polybrominated diphenyl ether (PBDE) flame retardants as potential autism risk factors.

Author information

  • 1Wadsworth Center, NY State Department of Health, 120 New Scotland Ave., Albany, NY 12208, United States. messer@wadsworth.org

Abstract

Brominated flame retardants, including Polybrominated diphenyl ethers (PBDEs) have been used at increasing levels in home furnishings and electronics over the past 25 years. They have also become widespread environmental pollutants. High PBDE levels have been detected in food, household dust, and indoor air, with subsequent appearance in animal and human tissues. This minireview summarizes studies on the extent to which these compounds can act as potent thyroid hormone mimetics, and emerging studies on long-term neurological effects of acute administration of PBDEs during development. When these data are considered in combination with the extensive literature on stage-dependent effects of thyroid hormone on aspects of brain development that are also implicated in autistic brains, a hypothesis that PBDEs might also serve as autism risk factors emerges. Studies designed to explicitly test this hypothesis will require chronic exposure paradigms, and specific body burden and behavioral monitoring in animal models. Such testing may help to prioritize extensive human epidemiological studies, as well as offer protocols for evaluation of future compounds.

Copyright 2010 Elsevier Inc. All rights reserved.

PMID:
20100501
[PubMed - indexed for MEDLINE]
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Elsevier Science
    Loading ...
    Write to the Help Desk