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J Am Chem Soc. 2010 Feb 17;132(6):2024-8. doi: 10.1021/ja9094439.

Highly specific dual enzyme-mediated payload release from peptide-coated silica particles.

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  • 1School of Chemical Sciences, Dublin City University, Dublin 9, Ireland.


Stimuli-responsive gate mechanisms offer potential for the controlled passage of payload molecules from a porous carrier vehicle on-demand. We describe a method for the enzyme-mediated release of macromolecular guest molecules from inorganic silica particles coated with a bioactive peptide shell, synthesized precisely by Fmoc chemistry. Specific enzymatic hydrolysis of the peptide shell removes the bulky peptide-terminated Fmoc groups, permitting the selective release of previously entrapped guest molecules.

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