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Mar Drugs. 2009 Nov 18;7(4):605-23. doi: 10.3390/md7040605.

Marine benthic diatoms contain compounds able to induce leukemia cell death and modulate blood platelet activity.

Author information

  • 1Department of Biology, University of Bergen, Jahnebakken 5, Bergen, Norway. siv.prestegard@bio.uib.no

Abstract

In spite of the high abundance and species diversity of diatoms, only a few bioactive compounds from them have been described. The present study reveals a high number of mammalian cell death inducing substances in biofilm-associated diatoms sampled from the intertidal zone. Extracts from the genera Melosira, Amphora, Phaeodactylum and Nitzschia were all found to induce leukemia cell death, with either classical apoptotic or autophagic features. Several extracts also contained inhibitors of thrombin-induced blood platelet activation. Some of this activity was caused by a high content of adenosine in the diatoms, ranging from 0.07 to 0.31 microg/mg dry weight. However, most of the bioactivity was adenosine deaminase-resistant. An adenosine deaminase-resistant active fraction from one of the extracts was partially purified and shown to induce apoptosis with a distinct phenotype. The results show that benthic diatoms typically found in the intertidal zone may represent a richer source of interesting bioactive compounds than hitherto recognized.

KEYWORDS:

Amphora sp.; Melosira sp.; Nitzshia pusilla; Phaeodactylum tricornutum; adenosine; apoptosis; bioactivity; blood platelets; diatoms; drug discovery; natural products

PMID:
20098602
[PubMed - indexed for MEDLINE]
PMCID:
PMC2810217
Free PMC Article
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