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Nat Rev Endocrinol. 2010 Feb;6(2):67-9. doi: 10.1038/nrendo.2009.267.

Pituitary gland: predictors of acromegaly-associated mortality.

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  • 1Pituitary Center, Division of Endocrinology, Diabetes and Metabolism, Cedars Sinai Medical Center, 8700 Beverly Boulevard, Davis Building, Room 3066, Los Angeles, CA 90048, USA. benshlomoa@cshs.org


Mortality rates are increased in acromegaly. previous studies have shown that growth hormone and insulin-like growth factor 1 levels, male gender,age, hypertension, delayed diagnosis and prior pituitary radiotherapy are independent predictors of increased mortality. A new study by Sherlock et al. now adds adrenal insufficiency and hydrocortisone replacement dose to the list of independent predictors of acromegaly-associated mortality.

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