Display Settings:

Format

Send to:

Choose Destination
See comment in PubMed Commons below
Neurobiol Dis. 2010 May;38(2):219-25. doi: 10.1016/j.nbd.2010.01.009. Epub 2010 Jan 20.

Occupational exposure to PCBs reduces striatal dopamine transporter densities only in women: a beta-CIT imaging study.

Author information

  • 1Wadsworth Center, New York State Department of Health, Albany, NY 12201-0509, USA. seegal@wadsworth.org

Abstract

We hypothesize that occupational exposure to PCBs is associated with a reduction in central dopamine (DA) similar to changes previously seen in PCB exposed adult non-human primates. To test that hypothesis, we used [(123)I]beta-CIT SPECT imaging to estimate basal ganglia DA transporter density in former capacitor workers. Women, but not men, showed an inverse relationship between lipid-adjusted total serum PCB concentrations and DA transporter densities in the absence of differences in serum PCB concentrations. These sex differences may reflect age-related reductions in the levels of gonadal hormones since these hormones have been shown experimentally to alter response to DA neurotoxicants. These findings may aid in better understanding the roles that sex and age play in modifying central DA function following exposure, not only to PCBs, but also to other DA neurotoxicants as well as further elucidating the role of gonadal hormones in influencing the initiation and/or progression of neurodegenerative disorders.

Copyright 2010 Elsevier Inc. All rights reserved.

PMID:
20096358
[PubMed - indexed for MEDLINE]
PMCID:
PMC2854241
Free PMC Article
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Elsevier Science Icon for PubMed Central
    Loading ...
    Write to the Help Desk