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Cell Signal. 2010 Jul;22(7):977-83. doi: 10.1016/j.cellsig.2010.01.010. Epub 2010 Jan 21.

Tumor necrosis factor-alpha mediated signaling in neuronal homeostasis and dysfunction.

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  • 1Department of Pharmacology and Physiology, University of Rochester Medical Center, Rochester, NY 14642, USA.

Abstract

Tumor necrosis factor-alpha (TNF-alpha) is a potent pro-inflammatory molecule, which upon engagement with its cognate receptors on target cells, triggers downstream signaling cascades that control a number of cellular processes related to cell viability, gene expression, ion homeostasis, and synaptic integrity. In the central nervous system (CNS), TNF-alpha is produced by brain-resident astrocytes, microglia, and neurons in response to numerous intrinsic and extrinsic stimuli. This review will summarize the key events that lead to TNF-alpha elaboration in the CNS, and the effects that these inflammatory signals impart on neuronal signaling in the context of homeostasis and neuropathology.

(c) 2010 Elsevier Inc. All rights reserved.

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