Display Settings:

Format

Send to:

Choose Destination
See comment in PubMed Commons below
Cell Signal. 2010 Jul;22(7):977-83. doi: 10.1016/j.cellsig.2010.01.010. Epub 2010 Jan 21.

Tumor necrosis factor-alpha mediated signaling in neuronal homeostasis and dysfunction.

Author information

  • 1Department of Pharmacology and Physiology, University of Rochester Medical Center, Rochester, NY 14642, USA.

Abstract

Tumor necrosis factor-alpha (TNF-alpha) is a potent pro-inflammatory molecule, which upon engagement with its cognate receptors on target cells, triggers downstream signaling cascades that control a number of cellular processes related to cell viability, gene expression, ion homeostasis, and synaptic integrity. In the central nervous system (CNS), TNF-alpha is produced by brain-resident astrocytes, microglia, and neurons in response to numerous intrinsic and extrinsic stimuli. This review will summarize the key events that lead to TNF-alpha elaboration in the CNS, and the effects that these inflammatory signals impart on neuronal signaling in the context of homeostasis and neuropathology.

(c) 2010 Elsevier Inc. All rights reserved.

PMID:
20096353
[PubMed - indexed for MEDLINE]
PMCID:
PMC2860549
Free PMC Article

Images from this publication.See all images (3)Free text

Figure 1
Figure 2
Figure 3
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Icon for Elsevier Science Icon for PubMed Central
    Loading ...
    Write to the Help Desk