Arch Virol. 2010 Feb;155(2):247-50. Epub 2009 Nov 29.

Interaction of hepatitis B virus core protein with human GIPC1.

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Institute of Biotechnology, Graiciuno 8, 02241, Vilnius, Lithuania. raimis@ibt.lt

Abstract

Up to now, little is known about hepatitis B virus core protein (HBc) interactions with host-cell proteins, although such interactions might be essential for virus propagation and pathogenicity. In this work, a human liver cDNA library was screened for proteins interacting with HBc. Among several HBc-interacting partners selected, it interacted most strongly with the human protein GIPC1. A common protein interaction domain, PDZ, was identified as the region that is sufficient for the interaction with HBc. The core protein has a putative C-terminal PDZ-interacting motif, and this sequence proved to be important for the interaction with GIPC1.

PMID:: 20091192; [PubMed - indexed for MEDLINE]

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