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Phys Med Biol. 2010 Feb 21;55(4):947-62. doi: 10.1088/0031-9155/55/4/003. Epub 2010 Jan 20.

A tetrahedron-based inhomogeneous Monte Carlo optical simulator.

Author information

  • 1School of Biomedical Engineering and Sciences, Virginia Tech, Blacksburg, VA, USA. hhshen@vt.edu

Abstract

Optical imaging has been widely applied in preclinical and clinical applications. Fifteen years ago, an efficient Monte Carlo program 'MCML' was developed for use with multi-layered turbid media and has gained popularity in the field of biophotonics. Currently, there is an increasingly pressing need for simulating tools more powerful than MCML in order to study light propagation phenomena in complex inhomogeneous objects, such as the mouse. Here we report a tetrahedron-based inhomogeneous Monte Carlo optical simulator (TIM-OS) to address this issue. By modeling an object as a tetrahedron-based inhomogeneous finite-element mesh, TIM-OS can determine the photon-triangle interaction recursively and rapidly. In numerical simulation, we have demonstrated the correctness and efficiency of TIM-OS.

PMID:
20090182
[PubMed - indexed for MEDLINE]
PMCID:
PMC2858330
Free PMC Article

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