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HECT E3 ubiquitin ligase Nedd4-1 ubiquitinates ACK and regulates epidermal growth factor (EGF)-induced degradation of EGF receptor and ACK.
Lin Q, Wang J, Childress C, Sudol M, Carey DJ, Yang W.
Mol Cell Biol. 2010 Mar;30(6):1541-54. Epub 2010 Jan 19.
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Down-regulation of active ACK1 is mediated by association with the E3 ubiquitin ligase Nedd4-2.
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