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Proc Soc Exp Biol Med. 1991 Apr;196(4):367-73.

Homing of hemopoietic progenitor cells to the marrow.

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  • 1Department of Veterans Affairs Medical Center, Jackson, Mississippi.

Abstract

The recognition of hemopoietic stem cell after intravenous transplantation of marrow cells occurs initially by a lectin moiety on the surface of marrow sinus endothelium. The cell is then transported across the endothelial cytoplasm much in the way that a soluble ligand, such as transferrin, is transported. In the extravascular compartment, the cell binds to lineage-specific stromal cells. This mechanism, known as homing, is mediated by a lectin-glycoconjugate interaction, the lectin being on the surface of progenitor cell with specificity for galactosyl and mannosyl residues. The binding is subsequently stabilized by membrane-bound proteoglycans, integrin-like receptors, and fibronectin.

PMID:
2008437
[PubMed - indexed for MEDLINE]
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