Nat Immunol. 2010 Feb;11(2):114-20. Epub 2010 Jan 19.

Effectors and memories: Bcl-6 and Blimp-1 in T and B lymphocyte differentiation.

Source

Division of Vaccine Discovery, La Jolla Institute for Allergy and Immunology, La Jolla, California, USA. shane@liai.org

Abstract

Bcl-6 and Blimp-1 have recently been identified as key transcriptional regulators of effector and memory differentiation in CD4(+) T cells and CD8(+) T cells. Bcl-6 and Blimp-1 were previously known to be critical regulators of effector and memory differentiation of B lymphocytes. The new findings unexpectedly point to the Bcl-6 and Blimp-1 regulatory axis as a ubiquitous mechanism for controlling effector and memory lymphocyte differentiation and function. Bcl-6 and Blimp-1 are antagonistic transcription factors and can function as a self-reinforcing genetic switch for cell-fate decisions. However, their influences in different lymphocytes are complex. Here we review and examine the commonalities and differences in the functions of these transcription factors in CD4(+) follicular helper T(FH) lymphocytes, effector CD8(+) T lymphocytes and B lymphocytes.

PMID:: 20084069; [PubMed - indexed for MEDLINE]
PMCID:: PMC2864556

Free PMC Article

Images from this publication.See all images (4) Free text

Publication Types, MeSH Terms, Substances, Grant Support

Publication Types

MeSH Terms

Substances

Grant Support

LinkOut - more resources

Full Text Sources

Other Literature Sources

Supplemental Content

Save items

Related citations in PubMed

Review Regulation and functions of Blimp-1 in T and B lymphocytes. [Annu Rev Immunol. 2008]
Review Regulation and functions of Blimp-1 in T and B lymphocytes.
Martins G, Calame K. Annu Rev Immunol. 2008; 26:133-69.
Repression of AP-1 function: a mechanism for the regulation of Blimp-1 expression and B lymphocyte differentiation by the B cell lymphoma-6 protooncogene. [J Immunol. 2002]
Repression of AP-1 function: a mechanism for the regulation of Blimp-1 expression and B lymphocyte differentiation by the B cell lymphoma-6 protooncogene.
Vasanwala FH, Kusam S, Toney LM, Dent AL. J Immunol. 2002 Aug 15; 169(4):1922-9.
Transcriptional repressor Blimp-1 is essential for T cell homeostasis and self-tolerance. [Nat Immunol. 2006]
Transcriptional repressor Blimp-1 is essential for T cell homeostasis and self-tolerance.
Kallies A, Hawkins ED, Belz GT, Metcalf D, Hommel M, Corcoran LM, Hodgkin PD, Nutt SL. Nat Immunol. 2006 May; 7(5):466-74. Epub 2006 Mar 26.
Differential involvement of the transcription factor Blimp-1 in T cell-independent and -dependent B cell differentiation to plasma cells. [J Immunol. 1999]
Differential involvement of the transcription factor Blimp-1 in T cell-independent and -dependent B cell differentiation to plasma cells.
Soro PG, Morales-A P, Martínez-M JA, Morales-A S, Copín SG, Marcos MA, Gaspar ML. J Immunol. 1999 Jul 15; 163(2):611-7.
Review Germinal center B and follicular helper T cells: siblings, cousins or just good friends? [Nat Immunol. 2011]
Review Germinal center B and follicular helper T cells: siblings, cousins or just good friends?
Nutt SL, Tarlinton DM. Nat Immunol. 2011 Jun; 12(6):472-7.

See reviews... See all...

Cited by 28 PubMed Central articles

Activation of OX40 prolongs and exacerbates autoimmune experimental uveitis. [Invest Ophthalmol Vis Sci. 2011]
Activation of OX40 prolongs and exacerbates autoimmune experimental uveitis.
Wu X, Rosenbaum JT, Adamus G, Zhang GL, Duan J, Weinberg A, Zhang Z. Invest Ophthalmol Vis Sci. 2011 Oct; 52(11):8520-6. Epub 2011 Oct 31.
Synergy of brief activation of CD8 T-cells in the presence of IL-12 and adoptive transfer into lymphopenic hosts promotes tumor clearance and anti-tumor memory. [Am J Cancer Res. 2011]
Synergy of brief activation of CD8 T-cells in the presence of IL-12 and adoptive transfer into lymphopenic hosts promotes tumor clearance and anti-tumor memory.
Díaz-Montero CM, Naga O, Zidan AA, Salem ML, Pallin M, Parmigiani A, Walker G, Wieder E, Komanduri K, Cole DJ, et al. Am J Cancer Res. 2011 Aug 30; 1(7):882-96.
Human tonsil B-cell lymphoma 6 (BCL6)-expressing CD4+ T-cell subset specialized for B-cell help outside germinal centers. [Proc Natl Acad Sci U S A. 2011]
Human tonsil B-cell lymphoma 6 (BCL6)-expressing CD4+ T-cell subset specialized for B-cell help outside germinal centers.
Bentebibel SE, Schmitt N, Banchereau J, Ueno H. Proc Natl Acad Sci U S A. 2011 Aug 16; 108(33):E488-97. Epub 2011 Aug 1.

See all...

Related information

Related Citations
Calculated set of PubMed citations closely related to the selected article(s) retrieved using a word weight algorithm. Related articles are displayed in ranked order from most to least relevant, with the “linked from” citation displayed first.
References for this PMC Article
Citation referenced in PubMed article. Only valid for PubMed citations that are also in PMC.
Substance (MeSH Keyword)
PubChem chemical substance (submitted) records that are classified under the same Medical Subject Headings (MeSH) controlled vocabulary as the current articles.
Free in PMC
Free full text articles in PMC
Cited in PMC
Full-text articles in the PubMed Central Database that cite the current articles.

Recent activity

Clear Turn Off Turn On

Effectors and memories: Bcl-6 and Blimp-1 in T and B lymphocyte differentiation.
Effectors and memories: Bcl-6 and Blimp-1 in T and B lymphocyte differentiation.
Nat Immunol. 2010 Feb ;11(2):114-20. Epub 2010 Jan 19 .

PubMed
The cost-effectiveness of genetic testing strategies for Lynch syndrome among ne...
The cost-effectiveness of genetic testing strategies for Lynch syndrome among newly diagnosed patients with colorectal cancer.
Genet Med. 2010 Feb ;12(2):93-104.

PubMed
Predictors for the selection of patients for abdominal CT after blunt trauma: a ...
Predictors for the selection of patients for abdominal CT after blunt trauma: a proposal for a diagnostic algorithm.
Ann Surg. 2010 Mar ;251(3):512-20.

PubMed
Can normal be more normal than normal?
Can normal be more normal than normal?
Crit Care Med. 2010 Feb ;38(2):737-8; author reply 738.

PubMed
Patient-ventilator interaction during pressure support ventilation and neurally ...
Patient-ventilator interaction during pressure support ventilation and neurally adjusted ventilatory assist.
Crit Care Med. 2010 Feb ;38(2):518-26.

PubMed

Your browsing activity is empty.

Activity recording is turned off.

Turn recording back on

PubMed

Result Filters

Display Settings:

Send to: