Int J Biol Markers. 2009 Oct-Dec;24(4):223-9.

Association of the AA genotype of the BCL2 (-938C>A) promoter polymorphism with better survival in ovarian cancer.

Heubner M, Wimberger P, Otterbach F, Kasimir-Bauer S, Siffert W, Kimmig R, Nückel H.

Source

Institute of Pharmacogenetics, Medical Faculty, University of Duisburg-Essen, Essen - Germany. Martin.heubner@uk-essen.de

Abstract

BACKGROUND:

Bcl-2 plays a key role in the regulation of apoptosis. Recently, a novel regulatory single nucleotide polymorphism (-938C>A) in the inhibitory P2 BCL2 promoter was described. In this study we investigated its potential association with survival in epithelial ovarian cancer.

EXPERIMENTAL DESIGN:

Patients (n=110) with primary epithelial ovarian cancer were retrospectively genotyped by pyrosequencing.

RESULTS:

Genotype distribution was not significantly different between 110 ovarian cancer patients and 120 healthy controls, suggesting that genotypes of this polymorphism do not increase the susceptibility to ovarian cancer. Kaplan-Meier curves showed a significant association of the AA genotype with increased survival (p=0.002). Multivariate analysis revealed that the BCL2-938AC/CC genotype (hazard ratio 4.5; p=0.003) was an independent prognostic factor compared to other prognostic factors such as age, histological grade or tumor stage.

CONCLUSION:

The results suggest a role for the BCL2-938C>A polymorphism as a marker for survival in patients with epithelial ovarian cancer.

PMID:: 20082279; [PubMed - indexed for MEDLINE]

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Research Support, Non-U.S. Gov't

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Proto-Oncogene Proteins c-bcl-2

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Pharmacogenomic Annotation 827857655 for PMID:20082279 [PharmGKB] - Pharmacogenomics Knowledge Base

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Related citations in PubMed

The AA genotype of the regulatory BCL2 promoter polymorphism ( 938C>A) is associated with a favorable outcome in lymph node negative invasive breast cancer patients. [Clin Cancer Res. 2007]
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Cited by 3 PubMed Central articles

A Polymorphism (rs1801018, Thr7Thr) of BCL2 is Associated with Papillary Thyroid Cancer in Korean Population. [Clin Exp Otorhinolaryngol. 2011]
A Polymorphism (rs1801018, Thr7Thr) of BCL2 is Associated with Papillary Thyroid Cancer in Korean Population.
Eun YG, Hong IK, Kim SK, Park HK, Kwon S, Chung DH, Kwon KH. Clin Exp Otorhinolaryngol. 2011 Sep; 4(3):149-54. Epub 2011 Sep 6.
BCL-2 (-938C > A) polymorphism is associated with breast cancer susceptibility. [BMC Med Genet. 2011]
BCL-2 (-938C > A) polymorphism is associated with breast cancer susceptibility.
Zhang N, Li X, Tao K, Jiang L, Ma T, Yan S, Yuan C, Moran MS, Liang F, Haffty BG, et al. BMC Med Genet. 2011 Apr 1; 12:48. Epub 2011 Apr 1.
Interactions between genetic polymorphisms in the apoptotic pathway and environmental factors on esophageal adenocarcinoma risk. [Carcinogenesis. 2011]
Interactions between genetic polymorphisms in the apoptotic pathway and environmental factors on esophageal adenocarcinoma risk.
Wu IC, Zhao Y, Zhai R, Liu CY, Chen F, Ter-Minassian M, Asomaning K, Su L, Heist RS, Kulke MH, et al. Carcinogenesis. 2011 Apr; 32(4):502-6. Epub 2011 Jan 6.

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