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Opt Lett. 2010 Jan 15;35(2):181-3. doi: 10.1364/OL.35.000181.

Two-photon microscopy by wavelength-swept pulses delivered through single-mode fiber.

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  • 1Harvard Medical School and Wellman Center for Photomedicine, Massachusetts General Hospital, 50 Blossom Street,BAR-8, Boston, Massachusetts 02114, USA.


Nonlinear microscopy through flexible fiber-optic catheters has potential in clinical diagnostic applications. Here, we demonstrate a new approach based on wavelength-swept narrowband pulses that permits simple fiber-optic delivery without need of the dispersion management and allows nonmechanical beam scanning. Using 0.86 ps pulses rapidly tuned from 789 nm to 822 nm at a sweep rate of 200 Hz, we demonstrate two-photon fluorescence and second-harmonic generation imaging through a 5-m-long standard single-mode fiber.

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