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    Science. 2010 Jan 15;327(5963):296-300.

    The NLRP3 inflammasome: a sensor for metabolic danger?

    Schroder K, Zhou R, Tschopp J.

    Source

    Department of Biochemistry, University of Lausanne, CH-1066 Epalinges, Switzerland.

    Abstract

    Interleukin-1beta (IL-1beta), reactive oxygen species (ROS), and thioredoxin-interacting protein (TXNIP) are all implicated in the pathogenesis of type 2 diabetes mellitus (T2DM). Here we review mechanisms directing IL-1beta production and its pathogenic role in islet dysfunction during chronic hyperglycemia. In doing so, we integrate previously disparate disease-driving mechanisms for IL-1beta, ROS, and TXNIP in T2DM into one unifying model in which the NLRP3 inflammasome plays a central role. The NLRP3 inflammasome also drives IL-1beta maturation and secretion in another disease of metabolic dysregulation, gout. Thus, we propose that the NLRP3 inflammasome contributes to the pathogenesis of T2DM and gout by functioning as a sensor for metabolic stress.

    PMID:
    20075245
    [PubMed - indexed for MEDLINE]

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